Dose integration and dose rate characteristics of a NiPAM polymer gel MRI dosimeter system

نویسندگان

  • Heather M Whitney
  • Daniel F Gochberg
  • C Waldenberg
  • A Karlsson Hauer
چکیده

The normoxic polymer gel dosimeter based on N-isopropyl acrylamide (NiPAM) is a promising full 3D-dosimeter with high spatial resolution and near tissue equivalency. NiPAM gel samples were irradiated to different doses using a linear accelerator. The absorbed dose was evaluated using MRI and statistical significance of the analysed data was calculated. The analysis was carried out using an in-house developed software. It was found that the gel dosimeter responded linearly to the absorbed dose. The gel exhibited a dose rate dependence, as well as a dependence on the sequential beam irradiation scheme. A higher dose rate, as well as a higher dose per sequential beam, resulted in a lower dose response.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Small field size dose-profile measurements: A comparison between Eclipse™ treatment planning system with NIPAM polymer gel dosimeter dose measurement

Introduction: Three physical conditions caused an external beam designated as a small field. The first is the loss of lateral charged particle equilibrium. The second is the effect of collimators on the primary photon source occlusion. The third condition is the size of the detector which is large compared to the field size. The most obvious perturbation effects in last condit...

متن کامل

The basic radiation properties of the N-isopropylacrylamide based polymer gel dosimeter

Background: In this study the basic radiation properties of N-isopropylacrylamaide polymer gel dosimeter were determined together with verification of its soft tissue equivalency. Materials and Methods: The NIPAM gel was prepared and irradiated approximately 2 h after manufacturing. The magnetic resonance (MR) images were made 24 h after irradiation. The nuclear magnetic resonance (NMR) respons...

متن کامل

Influencing Factors on Reproducibility and Stability of MRI NIPAM Polymer Gel Dosimeter.

INTRODUCTION At present, the polymer gel dosimeter is considered to be the best possible dosimeter for measuring 3-dimesional radiation dose distribution in radiotherapy. These gels are normally toxic; therefore, manufacturing, handling and discarding them require special attention. In order to find less toxic recipe, N-isopropyle acrylamide polymer gel (NIPAM) was introduced. In this study, th...

متن کامل

Investigation of dosimetric characteristic of NIPAM polymer gel using x-ray CT

Introduction: Polymer gel dosimeters contain chemical materials sensitive to the radiation which are polymerized by the radiation as a function of absorbed dose. So information of spatial dose distribution can be extracted by imaging from irradiated gel. Among imaging techniques, computed tomography (CT) poses as an attractive method because of practical advantages such as acce...

متن کامل

Verification of the PAGAT polymer gel dosimeter by photon beams using magnetic resonance imaging

Background: In this work investigation of the normoxic PAGAT polymer gel dosimeter such as sensitivity, the R2-dose response with post time and the percentage depth dose (PDD) of PAGAT polymer gel dosimeter have been undertaken. Materials and Methods: Using MRI, the formulation to give the maximum change in the transverse relaxation rate R2 was determined to be 4.5% N,N'-methylenbis- ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2017